Sensitivity of notochordal disc cells to mechanical loading: an experimental animal study
نویسندگان
چکیده
منابع مشابه
Mechanical loading affects the energy metabolism of intervertebral disc cells.
Research has shown that mechanical loading affects matrix biosynthesis of intervertebral disc (IVD) cells; however, the pathway(s) to this effect is currently unknown. Cellular matrix biosynthesis is an energy demanding process. The objective of this study was to investigate the effects of static and dynamic compressive loading on energy metabolism of IVD cells. Porcine annulus fibrosus (AF) an...
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T H E prime object of the studies to be described here was the investigation of the origin and epigenetic relations of the notochordal sheath. In addition, some data were collected concerning the effects on the development of the embryo of the removal of the notochord or its substitution by some other elongated strand of material, such as human hair. Many of the phenomena encountered in the lat...
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Recent studies suggest that notochordal cells (NCs) might be involved in intervertebral disc homeostasis, a role exploitable to counteract matrix degradation as observed during degeneration. This study aimed to evaluate the potential of NCs to promote matrix production by nucleus pulposus cells (NPCs) and to compare it to the currently proposed addition of bone marrow stromal cells (BMSCs). Usi...
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BACKGROUND Notochordal cells (NC) remain in the focus of research for regenerative therapy for the degenerated intervertebral disc (IVD) due to their progenitor status. Recent findings suggested their regenerative action on more mature disc cells, presumably by the secretion of specific factors, which has been described as notochordal cell conditioned medium (NCCM). The aim of this study was to...
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Spinal segments show non-linear behaviour under axial compression. It is unclear to what extent this behaviour is attributable to the different components of the segment. In this study, we quantified the separate contributions of vertebral bodies and intervertebral discs to creep of a segment. Secondly, we investigated the contribution of bone and osteochondral endplate (endplates including car...
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ژورنال
عنوان ژورنال: European Spine Journal
سال: 2009
ISSN: 0940-6719,1432-0932
DOI: 10.1007/s00586-009-1217-0